Bioss Inc.'s KMT5A (2A1) Monoclonal Antibody is a Rabbit monoclonal antibody. The KMT5A (2A1) Monoclonal Antibody was generated using KMT5A as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, and Western Blot.
Description
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration